Experimental infection of humans with filariae.
Identifieur interne : 012D41 ( Main/Exploration ); précédent : 012D40; suivant : 012D42Experimental infection of humans with filariae.
Auteurs : T B Nutman [États-Unis]Source :
- Reviews of infectious diseases [ 0162-0886 ]
Descripteurs français
- KwdFr :
- Animaux, Anticorps antihelminthe (biosynthèse), Brugia, Filaricides (usage thérapeutique), Filariose lymphatique (immunologie), Filariose lymphatique (parasitologie), Filariose lymphatique (traitement médicamenteux), Filarioses (immunologie), Filarioses (parasitologie), Filarioses (traitement médicamenteux), Humains, Immunité cellulaire, Loase (immunologie), Loase (parasitologie), Loase (traitement médicamenteux), Mansonellose (immunologie), Mansonellose (parasitologie), Mansonellose (traitement médicamenteux), Wuchereria bancrofti.
- MESH :
- biosynthèse : Anticorps antihelminthe.
- immunologie : Filariose lymphatique, Filarioses, Loase, Mansonellose.
- parasitologie : Filariose lymphatique, Filarioses, Loase, Mansonellose.
- traitement médicamenteux : Filariose lymphatique, Filarioses, Loase, Mansonellose.
- usage thérapeutique : Filaricides.
- Animaux, Brugia, Humains, Immunité cellulaire, Wuchereria bancrofti.
English descriptors
- KwdEn :
- Animals, Antibodies, Helminth (biosynthesis), Brugia, Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (parasitology), Filariasis (drug therapy), Filariasis (immunology), Filariasis (parasitology), Filaricides (therapeutic use), Humans, Immunity, Cellular, Loiasis (drug therapy), Loiasis (immunology), Loiasis (parasitology), Mansonelliasis (drug therapy), Mansonelliasis (immunology), Mansonelliasis (parasitology), Wuchereria bancrofti.
- MESH :
- chemical , biosynthesis : Antibodies, Helminth.
- drug therapy : Elephantiasis, Filarial, Filariasis, Loiasis, Mansonelliasis.
- immunology : Elephantiasis, Filarial, Filariasis, Loiasis, Mansonelliasis.
- parasitology : Elephantiasis, Filarial, Filariasis, Loiasis, Mansonelliasis.
- chemical , therapeutic use : Filaricides.
- Animals, Brugia, Humans, Immunity, Cellular, Wuchereria bancrofti.
Abstract
This report summarizes the findings of the 17 published studies involving humans who have been experimentally infected with filarial parasites. Over the past 60 years, 45 individuals have been deliberately infected with Wuchereria bancrofti, Brugia malayi, Brugia pahangi, Loa loa, Mansonella perstans, Mansonella ozzardi, and/or Onchocerca volvulus. The findings from these experimental infections of humans have helped define microfilarial survival and periodicity within human hosts, the prepatent period for the causative agents of lymphatic filariasis, etiologic agents for particular clinical syndromes, immunologic and hematologic consequences of filarial infection, and the role of chemotherapeutic agents in the prevention and treatment of filarial infections.
PubMed: 1962076
Affiliations:
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B" uniqKey="Nutman T" first="T B" last="Nutman">T B Nutman</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author></analytic><series><title level="j">Reviews of infectious diseases</title><idno type="ISSN">0162-0886</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Helminth (biosynthesis)</term><term>Brugia</term><term>Elephantiasis, Filarial (drug therapy)</term><term>Elephantiasis, Filarial (immunology)</term><term>Elephantiasis, Filarial 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cellulaire</term><term>Loase (immunologie)</term><term>Loase (parasitologie)</term><term>Loase (traitement médicamenteux)</term><term>Mansonellose (immunologie)</term><term>Mansonellose (parasitologie)</term><term>Mansonellose (traitement médicamenteux)</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antibodies, Helminth</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Anticorps antihelminthe</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Filariasis</term><term>Loiasis</term><term>Mansonelliasis</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Filarioses</term><term>Loase</term><term>Mansonellose</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Filariasis</term><term>Loiasis</term><term>Mansonelliasis</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Filarioses</term><term>Loase</term><term>Mansonellose</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Filariasis</term><term>Loiasis</term><term>Mansonelliasis</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Filaricides</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term><term>Filarioses</term><term>Loase</term><term>Mansonellose</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Filaricides</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Brugia</term><term>Humans</term><term>Immunity, Cellular</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Brugia</term><term>Humains</term><term>Immunité cellulaire</term><term>Wuchereria bancrofti</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This report summarizes the findings of the 17 published studies involving humans who have been experimentally infected with filarial parasites. Over the past 60 years, 45 individuals have been deliberately infected with Wuchereria bancrofti, Brugia malayi, Brugia pahangi, Loa loa, Mansonella perstans, Mansonella ozzardi, and/or Onchocerca volvulus. The findings from these experimental infections of humans have helped define microfilarial survival and periodicity within human hosts, the prepatent period for the causative agents of lymphatic filariasis, etiologic agents for particular clinical syndromes, immunologic and hematologic consequences of filarial infection, and the role of chemotherapeutic agents in the prevention and treatment of filarial infections.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Nutman, T B" sort="Nutman, T B" uniqKey="Nutman T" first="T B" last="Nutman">T B Nutman</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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